designing of progestrone drug nanoemulsion based on organic oils and optimization of its production conditions using chemometrics methods and study of drug release

Abstract: nowadays, the use of organic substances in the preparation of medicines has spread due to less toxicity and side effects. among these, the use of these materials in the preparation of nanomedicines in the form of tablets, injectable products or topical products is of particular importance. because the main and ultimate goal of preparing nanodrugs is to create less drug toxicity and increase the efficiency and effectiveness of the drug in the target organ. accordingly, in this study, progestrone nanomedicine is initially prepared as a nanoemulsion using an organic drug carrier for targeted drug delivery. then, using nanomaterial identification methods and analytical techniques, the dimensions of the nanoparticle are prepared and its properties are investigated. in the next step, using statistical analysis techniques, the optimal conditions for the preparation of the resulting nanomedicine will be analyzed. finally, the release of the drug in an environment similar to the target organ is evaluated using analytical techniques. nanoemulsion is prepared based on the phase change process. first, the most suitable oil, surfactant and cosurfactant are selected according to the solubility of the active ingredient in it using the solubility of the active ingredient in the same conditions. the organic phase consists of an organic oil, a mixture with a certain ratio of surfactant and cosurfactant, and an active ingredient such as progesterone at 75 °c, and homogenized by a stirrer at a rate of 600 rpm. the aqueous phase consisted of double distilled water and, if necessary, a preservative such as methyl paraben or propyl paraben was prepared separately at 75 °c.