captopril electrochemical oxidation using cpe-mil-53 as a novel electrochemical sensor and its quantitation in pharmaceutical and human plasma

Abstract: a metal-organic framework mil-53(cu), is suggested as a favorable novel analytical sensor for the quantitation of captopril in various samples. the electrode was made by modifying a carbon paste electrode with mil-53(cu). the electro-oxidation process of cap has been studied by cyclic voltammetric (cv) and square wave voltammetric (swv) in phosphate buffer solution (pbs) from ph 3.00–6.00 at a mil-53-cpe. the prepared electrode shows irreversible current responses for cap at the potential 1.23 v, while at the surface of the cpe electrode, a current response for cap cannot be observed at the potential 1.23 v. nanoparticles, mil-53(cu), were prepared via microwave procedure in this work. morphological characterization illustrated that mil-53(cu) was well-defined crystallinity, with porous structures and a specific surface area of 1.33 cm3/g and 5.80 m2/g, respectively. the consequences displayed that the active sites in the appearance of carbon paste cause the electrocatalytic activity of themil-53-cpe electrode into cap. the mil-53(cu) displayed the analysis of cap with a detection limit of 0.85 μm and a linear range of 1.60 – 416.00 μm. e0 was calculated to be 1.22, and the electron transfer rate constants (k0) were obtained to be 0.86 s-1. recovery evaluations were performed using pharmaceutical and spiked human plasma samples. the results show recoveries from 95.11% to 104.74% and 95.37% to 106.30% for analyses of drug tablets and human plasma, respectively.