electrochemical investigation of drug interaction of mesalazine with captopril in aqueous solution

Abstract: simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions. drugs that are taken simultaneously by a patient can already cause drug-drug interactions. drug-drug interactions is one of the most common causes of adverse drug reactions, but these interactions may also be responsible for an increase in clinical efficacy. mesalazine is an anti-inflammatory drug used to treat chronic inflammatory bowel disease. the control and treatment of chronic inflammatory bowel disease are long-term and may last for years so it may be used concomitantly with other such as blood pressure and blood sugar medications [1]. given that captopril is used to treat high blood pressure, and inflammatory diseases and to regulate the immune system. it is also an affordable drug for all age groups, including the elderly. it is possible for mesalazine to be taken concomitantly with captopril [2]. in this study, the electrochemical behavior of mesalazine in the presence of captopril was investigated using cyclic voltammetry and controlled-potential coulometry techniques in an aqueous buffer solution (ph~7). the results indicated that the peak structures and currents have changed and captopril has increased the mesalazine current value in cyclic voltammetry. corresponding products were electrochemically synthesized in aqueous solutions using a carbon electrode in a divided cell. these products were identified by spectroscopic methods (ft-ir, 1hnmr, and13cnmr).