a new cu-mof/bentonite hybrid as high-performance sensor for electrochemical determination of trazodone

Abstract: trazodone (tzd) is an antidepressant drug that belongs to the category of serotonin antagonist and reuptake inhibitor [1-4]. it is a triazolopyridine derivate and presents antidepressant, anxiolytic, and hypnotic effects, but produces lower anticholinergic side effects than other antidepressants [5]. tzd was first authorized in the 1970s for the treatment of depression. however, due to its heterogeneous mechanism, other therapeutic uses have been reported, namely, sleep disturbance, anxiety disorders, dementia psychosis, parkinsonism, trembling states, emotional disorders, or dyskinesia. some side effects are detailed for this antidepressant drug, including nausea, insomnia, agitation, dry mouth, constipation, headache, hypotension, blurred vision, and confusion. hepatotoxicity is another adverse effect reported for tzd, mainly by oxidative stress and by dysfunction in intracellular organelles. additionally, interactions with other therapeutic drugs are reported, namely for tzd and warfarin, and tzd and tandospirone. in this research, a novel, reliable and low-cost electrochemical sensor based on cu-mof/bentonite hybrid was designed and used for determination of trazodone (tzd). the morphology and chemical characterization of the modified electrode was studied by sem, tem, uv-vis, ft-ir, xrd. the electrochemical behavior of trazodone was investigated in detail. the cyclic voltammetric results show that modified glassy carbon electrode by cu-mof/bentonite hybrid can remarkably enhance electrocatalytic activity towards the oxidation of trazodone. under the optimal conditions, the linear dynamic ranges (ldrs) and limit of detections (lods) were obtained for trazodone 0.1–100 μm and 0.015 μm. the proposed electrode was successfully applied for the analysis of trazodone in pharmaceutical samples.