redox and ph-responsive nanocarriers based on boltorn® h40 and peg for tumor triggered targeted paclitaxel delivery: preparation and in vivo / invitro evaluation

The adoption of boltorn h40, a commercially available dendritic polymer of boltorn family containing multiple hydroxyl groups with various functionalities as a dendrimerbased starting core template for the generation of hyperbranched polymers, offers a straightforward solution to address this problem. in this contribution, hyperbranched polyester, boltorn® h40 (h40), a commercially available dendritic polymer of boltorn family containing multiple hydroxyl groups with various functionalities as a dendrimer based starting core template for the generation of hyperbranched polymers, were used and characterized for tumor triggered targeted drug delivery. multi-arm star amphiphilic block copolymers with approximately 32 arms based on a hyperbranched polyester, boltorn® h40 (h40) amphiphilic star copolymers (h40-ss-peg) with an a hyperbranched polyester, boltorn® h40 (h40), was used as the macroinitiator for the ring-opening polymerization and 3 3'-dithiodipropionic acid (dtdp) -a-poly(ethylene glycol) copolymer arms linked with acetal groups are synthesized using ring-opening polymerization and a copper (i)catalyzed alkyne-azide cycloaddition click reaction. the resulting multi-arm h40-dtdp (3 3'-dithiodipropionic acid) (h40-ss-cooh) was further reacted with carboxyl terminated poly(ethylene glycol) (peg-cooh) to form h40-ss-peg copolymers were synthesized as a nanocarrier for tumor-targeted paclitaxel delivery, anticancer drug ptx was covalently conjugated on the amphiphilic block copolymer arms by ph-responsive disulfide bonds.the block copolymer was characterized using 1h nmr, fourier-transform infrared spectroscopy (ftir), uv–visible spectrophotometry, dynamic light scattering )dls) and transmission electron microscopy (tem) analysis. the results indicate that this multifunctional nanocarrier is a significant breakthrough in developing a drug delivery vehicle that combines drug targeting as well as sensing and therapy at the same time.