effect of a nano-sized zeolite modified by the methionine on betahistine dihydrochloride

Abstract: betahistine dihydrochloride (bh.2hcl), an anti-vertigo histamine analog used in the treatment of ménière’s disease, undergoes extensive first-pass metabolism and suffers from short biological half-life. the aim of the present work was to develop and estimate controlled load and release of bh.2hcl from zeolite/methionine nanocomposite as a carrier to overcome this encumbrance. for this purpose, pretreated natural clinoptilolite (z) was modified by methionine (met) and the obtained modified zeolite nanoparticles (z-met) were used to design a system for the storage and release of bh. the adsorbed and released extents of the drug onto/from the modified zeolite were determined by uv-vis spectroscopy. sem, ft-ir, and xrd were used to characterize the samples. ft-ir results showed sufficient bh was loaded onto the raw zeolite, as well as loading of met onto the modified zeolite.