fabrication of a molecularly imprinted polymer modified glassy carbon electrode for the electrochemical determination of naproxen

Abstract: an electrochemical sensor based on the electro-polymerization of 4,4-methylene dianiline on a glassy carbon electrode has been proposed for the measurement of naproxen. the morphology of the uncoated glassy carbon electrode and the glassy carbon electrode modified with the imprinting polymer was examined by scanning electron microscopy. determination of naproxen has been made based on decreasing of current for pair [fe(cn)6]3- / [fe(cn)6]4- due to the occupation of naproxen complexing sites [1]. parameters affecting the signal including 4,4-methylene dianiline monomer concentration, number of electro-polymerization cycles, potential scan rate in electro-polymerization process, ph of electro-polymerization solution, effect of time (pre-concentration step), number of cycles to removing the pattern molecule from the surface of the modified electrode and ph of the measuring medium were optimized. also, the electrochemical parameters related to differential pulse voltammetry technique including pulse amplitude value, pulse life, and potential scan rate were optimized. under the optimum condition, the current change was linear relative to the concentration of naproxen. the detection limit, the inter- and intra-day standard deviations of the sensor were found. finally, the developed sensor was used to measure naproxen in real samples (urine and blood) and the results were satisfactory.