electrochemical investigation of the interactions of hydroxychloroquine and captopril in the treatment of patients with covid-19

Abstract: drug interactions occur when a drug's mechanism of action is disturbed by the concomitant administration substances such as foods, beverages or other drugs. despite the diminishing developments of covid-19, there is no drug still approved to have significant effects with no side effect on the treatment for covid-19 patients. based on the evidence, many antiviral and anti-inflammatory drugs have been authorized by the food and drug administration (fda) to treat the covid-19 patients even though not knowing the possible drug-drug interactions [1]. in coronavirus disease, hypertension and cardiovascular diseases are major risk factors for critical disease progression [2]. nowadays concomitant use of chloroquine (cq) and hydroxychloroquine (hcq) derivative (used for inflammatory diseases as a potential treatment in patients with quid 19) and captopril (for the treatment of hypertension) is very common. in this research the electrochemical behavior of hcq in the presence of captopril was investigated using cyclic voltammetry and controlled-potential coulometry techniques in aqueous buffer solution (ph~7). the results indicated that the peak structures and currents have changed and captopril has reduced the hcq current value in cyclic voltammetry. the type of interaction, possible reactions and proposed mechanisms were determined using the coulometric method. in order to ensure drug interaction, the synthesized products after separation identified by spectroscopic methods (ft-ir, 1hnmr, 13cnmr and ms). the observed homogeneous rate constants (kobs) were estimated by comparison of the experimental cyclic voltammetric responses with the digital simulated results.