coated wire thiopental ion-selective electrode based on imprinted polypyrrole as recognition element

Abstract: thiopental is a drug widely used as an intravenous agent for the rapid induction of general anesthesia. [1] it is also used as a supplement to other anesthetics and to induce sleep during anesthesia in balance with other medications. thiopental drugs can also be deadly, and taking this drug in high doses can cause euphoria, rape, and even suicide. it is important to diagnose brain death before organ donation, so it is necessary to measure this drug before it leaves the body's biological fluids [2, 3]. in this work, in order to detect thiopental anion in an aqueous solution, a coated wire solid-state ion-selective electrode (ise) based on doped polypyrrole with thiopental anion was prepared by electrochemical methods. the electrochemical polymerization was carried out with a three electrodes electrochemical system by using a potentiostat/ galvanostat instrument. a spherical head (1.0 mm diameter) platinum electrode was used as working electrode. the polymeric film as a recognition element was prepared with different electrochemical conditions in the presence of thiopental anion. then, the response behavior of fabricated sensors for detection of thiopental anion with different concentrations (10-7 – 10-2 m) was tested at various ph levels in aqueous solution. according to the calibration curve, the nernstian slope of about -57 mv/decade and correlation coefficient (r2) of 0.99 were obtained in optimum conditions. based on the results, the fabricated solid-state ise based on doped polypyrrole with thiopental anion is a promising candidate for detection and measurement of thiopental anion in pharmaceutical preparation and water samples.