construction of novel and nonenzymatic electrochemical biosensor with modification of carbon paste electrode with cr2o3 /psy nanocomposite for determination of pa in tablet sample

Abstract: paracetamol (pa) plays an important role in the pharmaceutical field due to its wide use as an antipyretic and pain reliever. limited use of pa has no harmful side effects, but excessive and addictive use of this compound can cause injury and death in some cases. monitoring the amount of pa in pharmaceutical formulations is essential for quality control as well as public health perspectives. recently, electrochemical techniques based on modified electrodes (sensors) have been widely used for the measurement of pharmaceutical compounds [1-3]. various composites can be used to modify the surface of the working electrode. the materials that can be used in the preparation of these composites are basically nanocomposites, including polymers, carbon nanomaterials, metal nanoparticles, etc. (cr2o3) nanoparticles were successfully fabricated and used for pa measurement with high sensitivity. the morphology and structure of nanocomposite were investigated by fe-sem, eds, mapping, atr-ir and xrd techniques. compared with cpe and psy/cpe, modified cr2o3/psy/cpe showed better electrocatalytic activity for pa oxidation. cyclic voltammetry and differential pulse voltammetry techniques were used for the measurements. the amount of surface conductivity was investigated by impedance technique and the results showed an increase in surface conductivity. the limit of detection (lod) obtained was 99.4 nm and the linear dynamic range (ldr) from 0.5 μm to 650.0 μm (s/n = 3) was observed. the fabricated sensor has good features such as high sensitivity, high reproducibility and reproducibility, low detection limit and fast response time. the results obtained from the real sample were quite satisfactory.