synthesis and characterization of zif-8 nanoparticles as an antibacterial biomaterial

Aim and background: metal-organic frameworks (mofs) are distinctive materials with noticeable pore patterns. in addition to serving as a drug delivery system, they can be utilized to store gas and catalyze reactions. due to its chemical and thermal stability, the series of zeolitic imidazolate frameworks (zifs) is a particularly valuable group of porous materials. several studies were conducted to generate biocompatible nanoparticles with the requisite shape and porosity for drug delivery and medical treatment. for instance, zif-8 was employed in medicinal applications by xia et al. and kohsari et al. methods: for the synthesis of zif-8, a solution of zinc nitrate hexahydrate and methyl imidazole in methanol was stirred for 5 h. following that, the solution was centrifuged, washed three times, and dried in an oven. results and discussion: the nanoparticles were characterized by various analyses including fe-sem, xrd, mtt, and antibacterial assay. the morphology of zif-8 nanoparticles has an average size of 62 nm with connected pores. the biological test determined promising cell viability and no toxicity at different concentrations of zif-8. the antibacterial assay shows high antibacterial properties for both gram-positive and gram-negative bacteria. conclusion: several approaches were used to successfully create zif-8 nanoparticles. antibacterial properties, cell viability, and even enhancement in cell growth were seen