niosome containing mirna-15a, combination of gene therapy and nanotechnology for treating prostate cancer

Aim and background: the combination of drug delivery and gene therapy could be considered a new approach for treating one of the most common types of cancer among men, prostate cancer. this study is aimed to synthesis and characterize niosomes containing mirna-15a for improving prostate cancer treatment.methods: firstly mirna-15a was synthesized on cationic niosomal system, then du-145, pc3 cancer cells, and hff normal cells were treated with none-loaded niosomes, free mirna-15a and mirna15-niposome and cell viability was calculated by mtt assay.results and discussion: along with appropriate features of niosomes, mtt results showed that the viability percentage of du-145 and pc3 cells treated with non-loaded niosomes, free-mirna-15a, and mirna-15a niosome were 100%-99%, 97%-98%, and 90%-88% respectively.conclusion: niosome containing mirna-15a opens a new safe window for the treatment of prostate cancer.