nonionic niosomes as a promising nanocarrier in drug delivery

Aim and background: niosomes can improve the targeting and controlled release of natural pharmaceutical compounds, solubility, and stability of pharmaceutical molecules. this study aimed to synthesize and characterize novel non-ionic niosomes as promising nanocarriers. methods: nano-noisome loaded with different drugs ( such as gallic acid and crocin) was prepared by thin layer hydration. different ratios of cholesterol, non-ionic surfactants (tween-60 and span-60), and polyethyleneglycol 4000 were mixed and size, stability, entrapment efficiency, and release profile of nanosystems were investigated by dls and uv-visible spectrophotometry. results and discussion: our results showed that drugs in nanoniosome-based systems improve biological activity, stability, and bioavailability. furthermore, the ratio of surfactants can influence niosome properties such as size, zeta potential, drug entrapment, and drug release. conclusion: a nanoniosome-based system optimizes pharmaceutical uses mainly by improving biological activity and stability.