targeted glutathione-sensitive nanoparticles for doxorubicin delivery tobreast cancer cells

Chitosan (cs), a biocompatible and biodegradable polymer, has been widely used as a potentialnanocarrier in recent years. although, the positive charge of the cs has limited its utilization as aneffective nanoparticle (nps) for the positive charge drugs. so, loading the dox, a positive chargeanticancer drug, into chitosan-based nps is challenging. herein, we offer a cs derivation polymerby covalent linkage to l-cysteine (l-cys) for reducing the enhancing the entrapment efficiency(ee%) of dox. accordingly, the targeted dox-loaded nps based on cs-cys copolymer withredox-responsive properties were synthesized. at first, the cs-cysnps-dox were synthesized byion-gelation method, then they were targeted by hyalouronic acid (ha). ultimately, they werecharacterized in terms of size, zeta potential, ee%, and morphology. also, in vitro drug releasewas analyzed. overall, the suggested nps demonstrated a high potential for targeted therapy andeffective applications in biomedical research.