studying the kinetic profiles of the simultaneous release of metformin-sitagliptin drugs as a combination drug from the polymer substrate by mcr-als method

Nowadays, the development of targeted drug delivery systems has reduced the side effects oftraditional drug use and also increased the effectiveness of drugs in the body [1]. in order to havea faster effect and cure some diseases, combined drugs are made. it is essential to use fast andreliable analytical techniques to determine the real release profiles of drugs in targeted pharmaceutical systems for combination drugs [2]. zipmet is a widely used combination drug forthe treatment of diabetes, which is made from two drugs, metformin and sitagliptin. in this work,to investigate the release profiles of these two drugs in the presence of each other, first, both drugswere loaded on the polyacrylic acid-co-2 hydroxyethyl methacrylate cross-linked with egdma(paahema-co-egdma) polymer substrate and then the simultaneous release of these two drugsfrom the polymer substrate in the buffer and plasma environment was investigated by recordingspectrophotometric spectra. the release profile of each drug was extracted from the obtained spectrophotometric data using the mcr-als technique. the results showed that the simultaneous release of metformin and sitagliptin drugs from the paahema-co-egdma substrate is faster in acidic ph than in basic and neutral ph. also, the comparison of the release profiles obtained from the mcr-als technique showed that the release rate of the metformin drug is higher than that of sitagliptin from the polymeric substrate. finally, the results of fitting the obtained profiles showed that korsmeyerpipas and ritger-pipas models achieve the best results for metformin and sitagliptin drugs in the presence of each other from the polymer substrate.