evaluation of the effect of limosilactobacillus reuteri and pediococcus acidilactici lactobacillus culture extract on wound healing infected with pseudomonas aeruginosa in rats

Pseudomonas aeruginosa is a common, gram-negative, facultative aerobic-anaerobic, rod-shaped organism that can cause disease in plants, animals, and humans. this bacterium is a species of considerable medical and veterinary importance and a multidrug-resistant pathogen that the reason for the ubiquitous presence of bacteria is the advanced antibiotic resistance mechanisms and its association with serious diseases, hospital-acquired infections such as ventilator-associated pneumonia and various sepsis syndromes. the most important effect of human probiotics is to prevent traveler s diarrhea. in animals, increasing the daily weight, improving the food conversion rate, reducing losses, and reducing diarrhea and diseases are the secondary effective factors of probiotics. today, bacterial therapy is a promising way to deal with drug-resistant infections, which prevents the replacement of pathogenic agents by using harmless bacteria. in recent years, the study of probiotic microorganisms and their use in the treatment of wound infections has attracted the attention of researchers. probiotics have the ability to increase the strength of the body s defense system, create anti-inflammatory reactions and accelerate the wound healing process by accumulating inflammatory cells at the wound site. lactobacillus reuteri is a well-studied probiotic found in a large number of mammals. especially meat and dairy products. in humans, lactobacillus reuteri is present in various parts of the body, including the digestive system, urinary tract, skin, and breast milk. the prevalence of lactobacillus reuteri varies from person to person. lactobacillus reuteri is one of the natural lactobacilli found in the digestive system of humans and animals.