igm and igg antibody titers in patients with severe and mild symptoms of covid-19 disease

Patients with sars-cov-2 may appear from asymptomatic to critical illnesses with multiple organ failure and dysfunction. antibody response in humans may be activated in the early stage of the infection and persist for a long time. this study aimed to determine the level of immunoglobulin m (igm) and immunoglobulin g (igg) antibodies in patients with severe and mild symptoms of covid-19 disease after three weeks of the initial symptoms and the relationship of the antibodies with the severity of symptoms and prognosis of the disease in patients. ninety blood samples were collected from positive-molecular covid-19 patients with severe respiratory symptoms hospitalized in the valiasr fasa hospital. also, 78 blood samples were taken from positive-molecular covid-19 patients with mild symptoms who were referred to covid-19 centers. the mean of the igm antibody titer was much less in patients with severe symptoms than with mild symptoms. to understand better the immune response, igg antibody titer was measured in severe and mild covid-19 patients three weeks after the onset of initial symptoms. igg indicated higher titer in patients with severe symptoms. the ratio of igg/igm titer was observed higher in patients with severe symptoms than in patients with mild symptoms. according to the lower igm antibody titer in patients with mild symptoms than the severe ones, the role of the immune response in the early stages of the disease as a determinant of the disease prognosis was confirmed. the higher igg in people with severe symptoms showed more involvement of the immune system with greater severity of symptoms. furthermore, the level of igg /igm titer was higher in severe infections than the mild ones.