a review of outstanding retinoblastoma researches on rb1 genes: focus on treatment by non-ionizing and ionizing radiation

Introduction: retinoblastoma (rb) is a malignant retinal tumor, which affects infants and children. this cancer happens through a mutation in the retinoblastoma tumor suppressor genes (rb1). inactivation of rb1 has been observed in more than 97% of all retinoblastoma patients with mutations. in recent years, rb treatment has developed significantly. rb’s treatment methods can be one or a combination of the following treatments, including chemotherapy, non-ionizing, or ionizing radiation. this article aimed to review each treatment method’s role and its effectiveness in the treatment of rb. several articles from 2004 to 2020 were reviewed in pubmed, web of science, google scholar, and scopus, based on the rb treatments, of which 73 were selected for this study.conclusion: it can be concluded that ionizing and non-ionizing radiation play an important role in treating retinoblastoma. it was also shown that a combination of radiation treatments is more effective than traditional therapeutic methods.ionized and non-ionized radiations can be used as an effective treatment to cure retinoblastoma.