a study on the therapeutic potential of carbon nanotube as drug delivery carrier for anticonvulsant application

Nanotechnology is providing exciting and new opportunities which are likely to revolutionize future clinical practice. the use of nanoparticles for biomedical applications is particularly exciting due to their huge potential for multi-modal approaches. this includes their use as drug delivery vectors, imaging contrast agents, hyperthermia systems and molecular targeting. their ability to cross biological barriers, for example the blood brain barrier, makes them attractive for potential treatments in neurological disorders. furthermore, various applications and challenges involved in the use of nps as biomaterials are also discussed following the future perspectives of the use of nps in biomedicine. there is also great hope that nanostructures will serve as platforms in future cancer therapies. current cancer fighting strategies consist primarily of surgery, radiation therapy and chemotherapy. each of these treatments is bound by a limit, known as the therapeutic window, which, if exceeded, causes undue harm to the patient. in the ongoing quest to improve our therapeutic arsenal, nanoparticles are emerging as exciting structures for a new generation of multi-modal therapeutics. within this context, carbon nanostructures are amongst the leading contenders as building blocks to deliver multi-function drug delivery platforms. recent advances on the development of novel approaches for functionalization, targeting and imaging via carbon nanostructures are discussed.carbon nanotubes (cnts) are the novel structures of nano sciences and technologies, which are expected to be variously applicable in the fields of life sciences. the electron-rich sidewalls make cnts as proper surfaces for physical interactions with other substances e.g., n-(4-carboxyphenyl) phthalimide (cpp) with anticonvulsant effect. the physical interactions between the cnt and cpp are possible through pi-pi interactions, which could be detected by the uv spectrophotometry. to this aim, the wavelengths of absorptions before and after interactions have been recorded to approve the existence of such interactions. the samples have been prepared by solving cpp in methanol and deionized water and the absorption at the maximum wavelength of 221 nm has been subsequently recorded. in the next step, the cnt and cpp have been mixed together in solution phase to make possible the physical interactions. the mixture has been sonicated and centrifuged for the uv absorption measurement. the results declared that the conditions of ph and storage time of samples could influence on the absorption at the maximum wavelength. the acidic or neutral ph were proper for making possibility of interactions at temperature range of 2–7 °c. thus, developing nanohybrids based on carbon nanomaterial conjugated to cpp will remarkably enhance the anti-cancer activity.