advances in functional organic-based nanosystems for rna delivery, targeting different organs

Nucleic acid therapy utilizing ribonucleic acid (rna) biomacromolecules has attracted considerable attention for being applied as preventive and therapeutic strategies in several diseases including cancer, inflammatory conditions, and neurodegenerative disorders. however, some properties like safety profile, synthesized under good manufacturing procedures, and the fact that rna molecules, unlike deoxyribonucleic acid (dna), does not require crossing the nuclear membrane for expression, made them suitable gene materials for being encapsulated in various nano-delivery carriers and delivered precisely to the site of interest. in this article, we summarize the application of organic nano-delivery systems for delivering the two most applied rna molecules, messenger rnas (mrnas) and small interfering rnas (sirnas) in different human diseases.