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cell membrane-coated biomaterials for bone cancer-targeted diagnosis and therapy: a critical update on osteosarcoma applications
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نویسنده
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lopes joana ,lopes daniela ,macário-soares ana ,ferreira-faria inês ,peixoto diana ,motallebi mahzad ,mohammad imran shair ,giram prabhanjan s. ,pires patrícia c. ,raza faisal
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منبع
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materials chemistry horizons - 2023 - دوره : 2 - شماره : 1 - صفحه:65 -79
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چکیده
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Cancer is a malignant disease of increasing concern on account of its high heterogeneity, high mortality and morbidity rates, as well as absence of targeted and effective therapeutic regimes. the recent introduction of biomimetic and nature-inspired principles in the development of nanosystems has significantly impacted cancer therapies and diagnosis. biomembrane-surface engineered nanosystems are bioinspired nanoconstructions equipped with cell-mimicking features to improve in vivo interactions with surrounding biological environments and cells. these next-generation nanosized delivery systems can enhance therapeutic efficacy and safety of conventional cancer therapies by providing highly specific, targeted, and safer nanomedicines. herein, we have discussed the unique features of cell membrane-coated biomimetic nanodevices (including superior biocompatibility, immune evasion and tissue-homing features) that allow for promising osteosarcoma-targeted diagnosis, therapy, and theranostics. we also summarized the recent advances on cell membrane- and hybrid cell membrane-coated nanosystems for both primary bone cancer and metastatic scenarios, especially prostate cancer-derived bone metastases. future perspectives and challenges towards successful clinical translation are also highlighted.
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کلیدواژه
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biomimetic coating ,bone cancer ,cell membrane-coated ,nanosystem ,hybrid cell membrane-coated ,osteosarcoma-targeted medicine
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آدرس
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university of coimbra, faculty of pharmacy, requimte/laqv, group of pharmaceutical technology, department of pharmaceutical technology, portugal, university of coimbra, university of coimbra, faculty of pharmacy, requimte/laqv, group of pharmaceutical technology, department of pharmaceutical technology, portugal, university of coimbra, faculty of pharmacy, requimte/laqv, group of pharmaceutical technology, department of pharmaceutical technology, portugal, university of coimbra, faculty of pharmacy, requimte/laqv, group of pharmaceutical technology, department of pharmaceutical technology, portugal, university of coimbra, faculty of pharmacy, requimte/laqv, group of pharmaceutical technology, department of pharmaceutical technology, portugal, universal scientific education and research network (usern), immunology board for transplantation and cell-based therapeutics (immuno_tact), iran. islamic azad university, yadegar-e-imam khomeini shahr-e-rey branch, department of biology, iran, university of north carolina at chapel hill, eshelman school of pharmacy, division of chemical biology and medicinal chemistry, usa, university at buffalo, department of pharmaceutical sciences, usa. state university of new york, department of pharmaceutical sciences, usa, university of coimbra, faculty of pharmacy, requimte/laqv, group of pharmaceutical technology, department of pharmaceutical technology, portugal. university of beira interior, health sciences research centre (cics-ubi), portugal, shanghai jiao tong university, school of pharmacy, china
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پست الکترونیکی
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faisalraza@sjtu.edu.cn
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Authors
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