efficient synthesis of bis(3-methylphenyl)sulfoxide aza macrocycles from a bis(3-methylphenyl)sulfoxide diester and diamine derivatives

Some bis(3-methylphenyl)sulfoxide aza macrocycles (3–8) were synthesized in high yields based on the conventional methods of the reaction of corresponding bis(3-methylphenyl)sulfoxide diester and diamines in refluxing methanol. bis(3-methylphenyl)sulfoxide diester was synthesized from the reaction of 2-[(2-hydroxy-5-methylphenyl)sulfinyl]-4-methylphenol and methyl chloroacetate. the structures of these compounds were confirmed using ir, 1h nmr, 13c nmr and mass spectroscopy.