preparation of polyhydroquinolines using nano cerium (iv) oxide/zinc oxide as a catalyst

Polyhydroquinolines derivatives are important compounds that perform a range of biological functions such as vasodilation, anti-atherosclerosis, liver protection, and anti-diabetic. several drugs such as nifedipine, nicardipine, and lacidipine feature a polyhydroxyquinoline scaffold. the common synthesis method of polyhydroquinolines is a one-step condensation reaction of dimedone, aldehydes with ethyl acetate and ammonia in the presence of various catalysts such as mcm-41, molecular iodine, bread yeast, etc. herein, we report cerium oxide/zinc oxide nanoparticle as an effective and economical catalyst for the four-component, one-pot reaction to synthesize polyhydroquinolines.