bi(otf)3 as a highly potent catalyst for the synthesis of mannich bases under milder conditions

A simple, eco-friendly friendly and efficient procedure for the synthesis of mannich baseshas been developed via multi-component and one-pot reactions of various aldehydes with aniline, and acetophenone and catalytic amount of bi(otf)3 reagent in a dcm solvent.the bi(otf)3 acts as a highly potent catalyst ( 0.5 to 1 mol%) for a for the synthesis of mannich base (1,3-diphenyl-3-(phenylamino)propan-1-one). this protocol is also compatible with a variety of hetero aldehyde carbonyl compounds in excellent yields. thus, this practical method is developed as a notable medium for these derivatives via a multicomponent reaction.