development of organ-on-chip for the study of placental pathologies: a ten-year study of literature published

Context: the placenta performs a crucial function in nutrient exchange, but studying this tissue poses a number of challenges. utilizing microfluidic and microfabrication technologies, a 3d placenta-on-a-chip model provides a biomimetic alternative for studying placental diseases and treatments.objectives: aim: to review and analyze the currently available placenta-on-chip data to study placental pathologies in patients.methods: by systematically searching the pubmed, scopus, and science direct databases, research papers that employed 3d printing techniques for the development of organoids and organ-on-chip (ooc) systems for in vitro experiments were gathered and scrutinized.results: when exposed to glucose transfer, placenta-on-a-chip mimics the features of an in vivo human placenta. microchips have the potential to become a platform for diagnostic purposes for placental diseases and a model for duplicating the important features of these diseases.conclusions: the microfluidic placenta-on-a-chip platform holds promise as an affordable solution with versatile applications. however, research is essential to develop a comprehensive in vitro pregnancy model in the future to expand our understanding of feto-maternal communication.