|
|
|
|
investigating the relationship between polymorphism rs406193 and the risk of prostate cancer
|
|
|
|
|
|
|
|
نویسنده
|
mohammed fawziah m. ,mohammadi amir ,shojaei najme
|
|
منبع
|
personalized and precision medicine journal - 2020 - دوره : 5 - شماره : 16 - صفحه:6 -8
|
|
چکیده
|
In many cancers, an increase in gene expression of dnmt3b has been reported. this enzyme inhibits the expression of many tumor suppressor genes through the methylation of the promoter sequence and plays a key role in the progression of cancer. in this study, the relationship between polymorphism rs406193 of this gene and the risk of prostate cancer in 60 samples was investigated. the results showed a significant association between genotype tt and the risk of prostate cancer (p=0.048). it is recommended that this study be repeated in larger populations and that the relationship between this polymorphism and gene expression be investigated.
|
|
کلیدواژه
|
prostate cancer ,epigenetic ,single nucleotide polymorphism ,dnmt3b
|
|
آدرس
|
faculty of allied health sciences, kuwait medical laboratory sciences, kuwait, university of mazandaran, faculty of basic sciences, department of molecular and cell biology, iran. tehran university of medical sciences, asthema and allergy reserch institute, childeren's medical centerfaculty of basic sciences, department of immunology, iran, personalized medicine research center of amitisgen, iran
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|