association between cdkal1 gene polymorphism and risk of type 2 diabetes in population of lorestan province

Diabetes mellitus is defined as a metabolic disorder characterized by chronic hyperglycemia. the more prevalent form, type 2 diabetes, usually begins as insulin resistance, a disorder in which the cells do not use insulin properly. t2dm is a complex multifactorial disease in which multiple genetic variants interact with environmental factors to trigger the disease. there is sufficient evidence that t2dm has a strong genetic basis. one of the identified candidate genes associated with type 2 diabetes is cdkal1, reduced expression of cdkal1 would result in enhanced activity of cdk5 in β cells, which would lead to decreased insulin secretion. in this study, the association of polymorphism rs10946398 of cdkal1 with type 2 diabetes was evaluated in 200 people by rflp-pcr method. no significant association was found between the genotypes of polymorphism rs10946398 and type 2 diabetes in the target population. it is suggested that this polymorphism association with type 2 diabetes in larger populations evaluated.