relationship between pai1 promoter 4g/5g polymorphism and stroke

Pai-1 has become recognized as a central molecule linking pathogenesis and progression of thrombotic vascular events, including stroke. clinical and experimental studies show that pai-1 deficiencies cause accelerated fibrinolysis and bleeding, whereas elevated pai-1 plasma levels are associated with vascular thrombosis. raised pai1 plasma levels are related to a 1-bp guanine deletion/insertion (4g/5g) polymorphism in the promoter of the pai1 gene. the 4g allele is associated with higher plasma pai1 transcription and activity. in the current study, the association of higher pai-1 plasma levels and the prevalence of the 4g/5g polymorphism in the pai-1 gene promoter region in young patients with stroke were explored. significantly, higher pai-1 levels were observed in patients when compared to controls (p =002). the 4g/5g polymorphisms were significantly associated with increased pai-1 levels, with the variant homozygous 4g/4g corresponding to mean values in patients versus controls.