mir-22-3p as a novel biomarker in rheumatoid arthritis

Rheumatoid arthritis (ra) is a chronic inflammatory autoimmune. early diagnosis of ra remains challenging. a significant portion of ra patients also experience unremitting symptoms despite treatment. mirna are involved in the regulation of autoimmunity- and inflammation-related processes. in this study, we evaluated the expression of mir-22-3p in serum of ra patients as a novel biomarker. expression level of this gene in the blood serum of 30 people with ra compared with 30 healthy individuals by the qrt-pcr method. results showed levels of mir22-3p were significantly higher in the serum of patients with ra in comparison with healthy control (p<0.0001). we suggest that mir 22-3p can be used as a biomarker in early detection and screening.