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relationship between lncrnas and multiple sclerosis (ms)
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نویسنده
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tahouri reyhaneh ,ghorbani valezaghard ghasem
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منبع
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personalized and precision medicine journal - 2023 - دوره : 8 - شماره : 28 - صفحه:13 -19
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چکیده
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Multiple sclerosis (ms), the most common inflammatory demyelinating illness of the central nervous system (cns), presents a range of clinical symptoms. the body’s immune system attacking myelin causes the transmission block in ms, which increases the electrical capacity of axons. studies suggest that epigenetic factors play a part in the development of ms. longer than 200 nucleotides in length and widely distributed, lncrnas are linear rna transcripts that cannot code for proteins. for instance, evidence suggests that lncrnas are essential for a number of cellular functions, including immune response regulation, epithelial mesenchymal transition (emt), cancer cell proliferation and metastasis, cellular homeostasis, and embryonic development. epigenetic mechanisms have been proven to have a significant impact on the pathophysiology of ms, and their participation has revealed the function of lncrnas as epigenetic regulatory molecules in molecular processes. the major subjects of this study have been the relationship between lncrnas and ms, the role of lncrna in the pathophysiology of the disease, and the diagnostic and prognostic potential of lncrna in ms.
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کلیدواژه
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multiple sclerosis ,rna ,lncrna ,autoimmune disease ,central nerve system
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آدرس
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islamic azad university science and research branch, department of cellular and molecular biology, iran, islamic azad university, ahar branch, department of molecular genetics, iran
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Authors
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