association of the kcnj11 rs5219 e23k polymorphism with type 2 diabetes

Diabetes mellitus (dm) is a major public health issue in worldwide. type 2 diabetes does not have a clear pattern of inheritance, although many affected individuals have at least one close family member, such as a parent or sibling, with the disease. the kcnj11 gene is a member of the potassium channel gene family. polymorphisms  in kcnj11  result  in  neonatal  diabetes and congenital hyper-insulinaemia, wherein the e23k (rs5219) polymorphism is linked with diabetes susceptibility where the k allele plays an important role in insulin secretion. in this study, we evaluate the frequency of these polymorphisms in a kurdish population of 85 with type 2 diabetes. e23k polymorphism of kcnj11 gene was genotyped by pcr-rflp method. heterozygous carriers for ag are more in non‑diabetic patients (p = 0.034).