effect of genetic factors on covid-19 susceptibility and severity: a review

Severe acute respiratory syndrome coronavirus 2 (sars-cov-2), is a severe infection with respiratory and systemic manifestations. this infectious disease has a complex course and manifests itself with various clinical presentations, ranging from asymptomatic infection to a severe clinical course. these variations in severity have raised the question of whether the genetic or epigenetic variations have a role in covid-19 susceptibility or severity, and that these factors can be used to predict the disease course. a whole-genome sequencing performed on 95 samples of sars-cov-2 identified 116 unique mutations, most of which were missense and synonymous. moreover, some studies have reported a relationship between the covid-19 severity and the genes ace and tmprss2. the present review provides an overview of different genes that have been found to be implicated or related to the susceptibility to covid-19 or its severity.