alterations in urine parameters following one week of hydrochlorothiazide consumption in hypertensive individuals

Introduction: hydrochlorothiazide is widely prescribed for managing hypertension. despite its extensive use, there is a significant lack of scientific literature addressing its impact on 24-hour urine parameters. this study aims to investigate these effects by comparing parameters derived from 24-hour urine collection tests before and after hydrochlorothiazide administration.methods: this prospective before-and-after study was conducted from 2021 to 2022 at the medical facilities affiliated with the islamic azad university, tehran medical sciences branch. adhering to university-approved research protocols, participants were instructed to provide 24-hour urine samples before initiating hydrochlorothiazide treatment. one week later, a second set of 24-hour urine samples was collected following the administration of hydrochlorothiazide. this methodology allowed for the comparison of urine parameters before and after the intervention.results: among the eight variables analyzed—volume, protein, creatinine, albumin, uric acid, citrate, and ph—six showed p-values greater than 0.05, indicating no statistically significant differences between the pre-and post-treatment tests. however, calcium and citrate levels exhibited p-values less than 0.05, indicating a significant decrease in their mean values following hydrochlorothiazide administration.conclusion: the study findings show a significant impact of hctz on urinary calcium and citrate levels, with both parameters demonstrating a statistically significant decrease after treatment.