مروری بر پیشرفت های اخیر در سنتز پرگابالین

S)-3-(aminomethyl)-5-methylhexanoic acid ((s)-pregabalin) is a δ -aminobutyric acid (gaba) analog, pregabalin is closely related to gabapentin (neurontin; pfizer), an alkylated analog of γ-amino-butyric acid (gaba), which acts as a main inhibitory neurotransmitter in the central nervous system. pregabalin is approved in us and europe for adjunctive therapy of partial seizures in adults, and also has been approved for the treatment of pain from diabetic neuropathy or post-herpetic neuralgia in adults. due to the increase in pregabalin consumption in recent years and the importance of enantioselective synthesis of the final product, in recent years, various ways have been presented for the synthesis and separation of enantiomers of this product. this review article provides an overview of recent progress in the synthesis of s-pregabalin covering only recent literature.