delorme-watkins or high-intensity pyramidic training protocol: which one has more effectiveness on adiponectin and tnf-α?

This study aimed to investigate the effects of two different resistance training protocols on tnf-α and adiponectin in young overweight men. sixty healthy overweight men (bmi ≥ 25 kg/m², age 20–30 years) were randomly assigned to three groups: experimental group 1 (eg1), experimental group 2 (eg2), and control group (cg). eg1 performed the delorme-watkins protocol, consisting of 3 sets of 10 repetitions at 50%, 75%, and 100% of 10rm, while eg2 performed hipt, consisting of 3 sets (set 1: 6 repetitions at 70% of 1rm; set 2: 4 repetitions at 80% of 1rm; set 3: 2 repetitions at 90% of 1rm). training lasted 8 weeks. tnf-α and adiponectin levels were measured pre- and post-intervention. one-way anova with tukey post hoc tests and paired-samples t-tests were used to analyze inter- and intra-group differences (α≤0.05). tnf-α significantly decreased in eg1 (p = 0.04), while adiponectin levels significantly increased in both eg1 (p = 0.02) and eg2 (p = 0.03) at post-test compared to pre-test. additionally, tnf-α levels were significantly lower in eg1 than in cg at post-test (p = 0.01). both resistance training protocols exerted beneficial effects on inflammatory and anti-inflammatory markers, potentially contributing to cardiovascular disease prevention. however, the delorme-watkins protocol resulted in a significantly greater reduction in tnf-α levels compared to hipt, whereas no significant between-group difference was observed for adiponectin.