investigating the correlation between glutathione peroxidase and interleukin-15 following aerobic exercise and probiotic supplementation in obese rats fed a high-fat diet

We investigate the effect of 6 weeks of aerobic training and probiotic supplementation on glycemic index and the correlation between glutathione peroxidase (gpx) and interleukin 15 (il-15) in rats fed a high-fat diet. 40 male wistar rats were divided into 5 groups (8 each): healthy control, high-fat diet (hfd), hfd+ aerobic exercise (tr), hfd+ probiotic supplement (sup) and hfd+tr+sup. rats in the hfd group received a special high-fat diet for 2 months before the main protocol. the rats in the training groups ran on a rodent treadmill for 6 weeks, 5 days a week. lactobacillus bifidus supplement was gavage to the rats of the supplemented groups in the amount of 109 cfu/ml after each round of training. the results of the statistical test showed that the hfd groups had a significant decrease in gpx compared to the healthy control group (p<0.05). however, only the hfd+tr+sup group showed a significant increase in gpx compared to the hfd and hfd+tr groups (p<0.05). in contrast, hfd+sup showed a significant increase in il-15 gene expression compared to the healthy control group. compared to the hfd group, the hfd+tr and hfd+tr+sup groups showed a decrease and the hfd+sup group showed a significant increase in il-15 gene expression (p<0.05). the correlation between gpx and il-15 was not confirmed (p<0.05). it seems that exercise training and lactobacillus supplementation are effective in regulating glucose, gpx and il-15 indices after hfd. however, more studies should be done for the relationship and cross talk between antioxidant indices and il-15.