effect of six weeks of interval training and curcumin consumption on apolipoprotein a and b in diabetic male rats

The present study was conducted to investigate the effect of six weeks of intermittent exercise and curcumin consumption on plasma apo a and apo b concentrations in male wistar rats. 30 male wistar rats were randomly divided into six groups (5 rats in each group): control, diabetic, healthy intermittent exercise, intermittent exercise diabetes, curcumin diabetes and curcumin exercise diabetes. diabetes was induced by intraperitoneal injection of streptozotocin poison (50 mg/kg). intermittent training consisted of 5-12 bouts of intense work (75 to 100% of maximum speed) of 60 seconds with active rest intervals of 75 seconds, six days a week for six weeks. curcumin was fed to animals by gavage at a dose of 50 mg per kilogram of body weight. the results demonstrated that diabetes induction significantly decreased plasma apo a concentration (p≤0.01) and increased plasma apo b concentration (p≤0.01). intermittent training caused a significant increase in apo a and a significant decrease in apo b plasma in diabetic rats. also, it was found that six weeks of curcumin consumption significantly increased the concentration of apo a in plasma and decreased the concentration of apo b and the ratio of apo b to apo a (p≤0.01). at end, the results of the present study showed that intermittent exercise, curcumin and the combination of two interventions improve the disorders caused by diabetes in apolipoproteins.