the effect of high-intensity interval training on il-22 and stat3 gene expression of liver tissue in steatosis animal model

Inflammation is a major component of almost all acute and chronic liver disorders, including non-alcoholic fatty liver disease. this study aimed to investigate the effect of high-intensity interval training on il-22 and stat3 gene expression of liver tissue in steatosis animal model. in this experimental study, 32 rats (weighing 200-250 gr) were selected and randomly divided into 4 groups including healthy control, fatty liver, hiit and fatty liver + hiit group. rats were infected with fatty liver by oral tetracycline at a dose of 140 mg/kg (soluble in 2 ml of water) for 7 days. the hiit exercise program performed on treadmill five sessions per week for 5 weeks. the il-22 and stat3 gene expressions in the liver tissue of samples were measured by real time pcr. data were analyzed by one-way anova and tukey post hoc tests at significance level p <0.05. the results showed that the gene expression of il-22 in liver tissue in hiit group and fatty liver + hiit was significantly lower than that in the fatty liver group (p = 0.001). also, the gene expression of stat3 in liver tissue in hiit group and fatty liver + hiit was significantly higher than that in the fatty liver group (p = 0.001). according to the results, the hiit training program seems to help improve the liver steatosis.