the effect of high-intensity interval swimming training on ulk and tsc1/2 proteins of hippocampus tissue in elderly rats

Understanding the cellular and molecular mechanisms that regulate aging reduces the possibility of dependence on age-related diseases. exercise treatment strategies reduce the burden of aging-related illness, disability, and premature death in the elderly. the aim of this study was to evaluate the effect of high-intensity interval swimming training on ulk and tsc1/2 proteins of hippocampus tissue in elderly rats. in this experimental study, 16 elderly male sprague dawley rats (20 months old and mean weight 300-450 g) were divided into two groups of control and high-intensity interval swimming training. high-intensity interval swimming training consisted of 14 bouts 20-second swimming sessions with 10 seconds of rest between each session for six weeks (three days a week). the content of ulk and tsc1/2 proteins in hippocampal tissue was measured by western blotting. data were analyzed using independent t-test at the p<0.05. the results showed that high-intensity interval swimming training caused significant increase in content of ulk protein of hippocampus tissue in elderly rats (p=0.010). also, high-intensity interval swimming training caused significant decrease in content of tsc1/2 protein of hippocampus tissue in elderly rats (p=0.010). according to the results, it seems that high-intensity interval swimming training can help improve the homeostasis regulatory pathways in hippocampal neurons in the elderly animal model.