influence of high intensity interval training on adipose tissue pai-2 and mmp-2 mrnas expression in rat with high-fat diet-induced metabolic syndrome

The aim of this study was to investigate the influence of high intensity interval training on adipose tissue pai-2 and mmp-2 mrnas expression in rat with high-fat diet-induced metabolic syndrome. in this experimental study, 32 male wistar rats (120 to 130 g) were selected and after 12 weeks of high-fat diet and modeling of metabolic syndrome were randomly divided into 4 groups: control, metabolic syndrome (mets), high intensity interval training (hiit) and mets + hiit. the hiit program included 5 to 10 intense running on the treadmill with an intensity of 80 to 95% of the maximum speed and in slow running with a speed of 55% of the maximum speed with a zero slope of the treadmill for 8 weeks. data were analyzed using one-way analysis of variance (anova). the results of one-way analysis of variance showed that there was a difference between the mean expression of mmp-2 and pai-2 mrna in adipose tissue of male rats with metabolic syndrome in different groups (p = 0.001). however, hiit improve this gene after mets in adipose tissue (p<0.05). it seems that hiit program improve metabolic syndrome with controlling pai-2 mrna and have an anti-inflammatory effect in adipose tissue. however, it need to more studies especially on human sample.