the effect of 12 weeks of aerobic exercise intervention on bone mineral density, expression of lymphocyte alkaline phosphatase gene and bone turnover markers in overweight postmenopausal women: a randomized controlled trial

The aim of our study was to examine the effect of 12 weeks of moderate-intensity aerobic exercise on bone mineral density (bmd), lymphocyte alkaline phosphatase (alp) mrna expression, and biochemical markers of bone turnover in postmenopausal women (pmws). twenty-four healthy sedentary pmws aged 50-60 years were randomly assigned to exercise (ex, n=12) and control (c, n=12) groups. the ex group performed walking/jogging (50-60min/day, 3days/week at 65%-70% hrmax reserve) for 12-week while the c group participated in no intervention and continued their normal lifestyle. the bmd and lymphocyte alp mrna were determined by dxa and qrt-pcr, respectively. after 12 weeks, the increase in the lymphocyte alp mrna expression and its serum (p=0.008 and p=0.001), pth (p=0.001), vit-d (p=0.002), and vo2max (p=0.001) were significantly higher in the ex group compared to the c group, whereas body fat was significantly decreased (p=0.028). our study indicates that 12 weeks of moderate-intensity aerobic exercise intervention improves bone turnover by increasing the alp mrna expression, serum levels of pth, alp, and vit-d which can lead to the prevention of aging-induced osteopenia among pmws.