therapeutic effects of low dose acetylsalicylic acid on acute central serous chorioretinopathy: a prospective, interventional, single centre case series

Objective: central serous chorioretinopathy (cscr) is a common cause of central vision loss, primarily affecting men 20–60 years of age. this study aimed to investigate the efficacy of low-dose aspirin for the treatment of acute cscr.methods: totally 60 patients (60 eyes) with a history of acute csc on fenofibrate were randomized into two groups: group a was treated with aspirin 100 mg per day orally for 1 month followed by 100 mg on alternate days for 5 months by evaluation of visual acuity, mean subretinal fluid vertical diameter (sfvd), optical coherence tomography (oct), and central macular thickness (cmt) at baseline and follow up period.  group b received no medication and was considered as the control group. follow-up times were the first week, 1, 2, 3 and 6 months after treatment initiation.results: no differences were seen between the studied groups in terms of baseline bcva (p = 0.968) and baseline sfvd (p = 0.774). bcva improved, and sfvd was reduced significantly in the group a at all follow-up intervals compared with baseline values. aspirin intervention (group a), compared with no intervention group (group b), was statistically more effective in improving bcva (p < 0.001) and in reducing sfvd (p < 0.001) after 6 months. while 93.3% (n=28) of group a’s cases had no recurrences during the follow-up period, only 60.0% (n=18) of patients in the group b had a resolution of cscr with no recurrences.conclusion: more rapid visual rehabilitation with fewer recurrences of cscr were detected in the group a than in group b. these results demonstrated that orally administered aspirin may be a promising option for selected patients in the treatment of acute cscr.