Using Fe3o4@Fap@Ni As A Novel Nanocatalyst For Synthesis of Polyfunctional Indole-Pyrido[2,3-D]Pyrimidine Hybrids As Biologically Important Scaffoldsبیولوژیکی

Using fe3o4@fap@ni as a novel nanocatalyst for synthesis of polyfunctional indole-pyrido[2,3-d]pyrimidine hybrids as biologically important scaffoldssahar dastmard, manouchehr mamaghani*department of chemistry, faculty of sciences, university of guilan, p.o. box 41335-1914, rasht, iran.pyridopyrimidines especially pyrido[2,3-d]pyrimidines are important heterocyclic scaffolds that are present in bioactive compounds and drugs [1-4]. these compounds have shown biological activities such as antibacterial, anti-inflammatory, antitumor, antipyretic, fungicidal, antihypertensive, antimalarial, bronchodilator, cardiotonic, analgesic, antileishmanial and antifolate [5,6]. on the other hand, indoles engross a privileged cores in pharmaceuticals, natural products and material sciences. additionally, a number of significantt synthetic drugs contain an indole motif, including, fluvastatin, tadalafil, rizatriptan and sumatriptan.in the present research, we have developed a novel prtocol for the synthesis of indole-pyrido[2,3-d]pyrimidine hybrids by using fe3o4@fap@ni as a recyclable and impactful nanocatalyst. the structure of this nanocatalyst was confirmed by edx, xrd, fe-sem and ft-ir analyses. the catalytic activity of fe3o4@fap@ni nanoparticles was examined in the three-component synthesis of polyfunctional indole-substituted pyrido[2,3-d]pyrimidines (1). in this new method the products were obtained at high to excellent yields (75-95%) and short reaction times. references:[1] p. jahanshahi, m. mamaghani, f. haghbin, r. hossein nia, m. rassa, j. mol. struct. 1155 (2018) 520-529.[2] m. mamaghani, r. hossein nia, j. heterocycl. chem. 54(3) (2017) 1700-1722.[3] r. n. kumar, g. j. dev, n. rvikumar, d. k. swaroop, b. debanjan, g. bharath, b. naraiah, s. n. jain, a. g. rao, med. chem. lett. 26(12) (2016) 2927-2930.[4] x. gao, l. cen, f. li, r. wen, h. yan, h. yao, s. zhu, res. commun. 505 (3) (2018) 1-7.[5] j. r. piper, g. s. mccaleb, j. a. montgomery, r. l. kisliuk, f. m. sirotnaks, j. med. chem. 29(6) (1986) 1080-1087.[6] a. b. a. el-gazzar, h. n. hafez, med. chem. lett. 19 (2009) 3392-3397.