evaluating the effectiveness and stability of regenerative treatment and orthodontic tooth movement in stage iv periodontitis: a systematic review and meta-analysis

Background and aim: the present systematic review and meta-analysis aimed to evaluate the effectiveness and stability of regenerative treatment and orthodontic tooth movement in stage iv periodontitis.material and methods: for the present systematic review and meta-analysis study, international databases such as medline (pubmed and ovid), web of science, and scopus were searched until october 2024 using keywords relevant to the study objectives. stata/mp. v17 software was used to analyze data.results: the present study included ten studies. the present meta-analysis showed a mean reduction of 1.10 mm in probing depth (95% ci, -1.18mm, -1.03mm; p < 0.001), an attachment gain of 1.96 mm (95% ci, -2.13mm,1.78mm; p < 0.001), and radiographic bone level of -1.44 mm ( 95% ci -1.65mm, -1.22mm; p<0.001).conclusions: according to the one-year results of the present meta-analysis, an interdisciplinary approach can produce favorable and stable outcomes in motivated and cooperative patients with stage iv periodontitis who require orthodontic treatment.