the study of apelin-13 for the assessment of endothelial dysfunction in prehypertension and hypertension patients

Background and aim: hypertension is a leading global burden of deaths, coronary heart diseases, and stroke. hypertension causes low-grade chronic systemic inflammation associated with endothelial dysfunction and vascular complications. the present study aimed to assess apelin-13 levels in prehypertension and hypertension patients and find their association with oxidized low-density lipoprotein (ldl) and lipid profile.material and methods: sixty prehypertension and 60 hypertension with the age group of 35 to 50 years were selected, and 60 healthy age-matched subjects were selected as controls. beckman colter’s fully automated analyzer carried out serum apelin-13 and oxidized ldl estimated by enzyme-linked immunosorbent assay (elisa) and other routine investigations.results: apelin-13 levels were significantly increased in hypertensive patients compared to prehypertensive patients. a significant positive correlation was observed between apelin-13 and oxidized ldl and triglyceride levels. further, there was no significance observed between other lipid profile parameters.conclusions: apelin-13 is a vital factor for assessing endothelial dysfunction in hypertensive patients. reduction of apelin-13 may be beneficial in preventing vascular complications and coronary heart diseases in hypertensive patients.