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synthesis of alkyl nitrile derivatives by phosphorous ionic liquid under solvent free conditions
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DOR
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20.1001.2.0021079099.1400.8.1.25.5
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نویسنده
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batooie nasim
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منبع
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كنگره بين المللي رنگ و پوشش - 1400 - دوره : 8 - کنگره بین المللی رنگ و پوشش - کد همایش: 00210-79099 - صفحه:1 -1
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چکیده
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An operationally simple and green method for the one-pot synthesis of a wide range of alkyl nitrile derivatives under mild conditions, with excellent yields using hexyltriphenylphosphonium bromide (htpb) ionic liquid as a promoter and solvent, has been developed. this improved method furnishes in good yields alkyl nitrile derivatives starting from barbituric acid derivatives, various aromatic aldehydes, and sodium cyanide via the one-pot, three-component condensation reaction. the present green protocol is a clean, transition-metal-free, and environmentally friendly approach that offers many advantages including high to quantitative yields, low cost, ambient conditions, straightforward work-up, without using column chromatography and short reaction times.
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کلیدواژه
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green chemistry ,ionic liquid ,alkyl nitrile ,solvent free ,one-pot ,barbituric acid
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آدرس
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kermanshah university of medical sciences, medical biology research center, medical school, iran, razi vaccine and serum research institute northwest branch the country, iran, sharif university of technology, iran, kermanshah university of medical sciences,, iran, kermanshah university of medical sciences, iran, kermanshah university of medical sciences, iran, razi vaccine and serum research institute northwest branch the country, iran, razi vaccine and serum research institute northwest branch the country, iran
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Synthesis of Alkyl Nitrile Derivatives by Phosphorous Ionic Liquid Under Solvent Free Conditions
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Authors
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Batooie Nasim
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Abstract
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An operationally simple and green method for the one-pot synthesis of a wide range of alkyl nitrile derivatives under mild conditions, with excellent yields using hexyltriphenylphosphonium bromide (HTPB) ionic liquid as a promoter and solvent, has been developed. This improved method furnishes in good yields alkyl nitrile derivatives starting from barbituric acid derivatives, various aromatic aldehydes, and sodium cyanide via the one-pot, three-component condensation reaction. The present green protocol is a clean, transition-metal-free, and environmentally friendly approach that offers many advantages including high to quantitative yields, low cost, ambient conditions, straightforward work-up, without using column chromatography and short reaction times.
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Keywords
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Green chemistry ,Ionic liquid ,Alkyl nitrile ,Solvent free ,One-pot ,Barbituric acid
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