efficient one-pot preparation of 2,4-dichloro-substituted pyrano[2,3‑d] pyrimidines and furo[2,3‑d]pyrimidines mediated by ceric ammonium nitrate in phosphorus ionic liquid

An efficient, green, and facile four-component reaction for the preparation of 2,4-dichlorosubstituted pyrano [2,3-d]pyrimidines and furo[2,3-d]-pyrimidines through the one-pot condensation of acetophenone derivatives, various aromatic aldehydes (or potassium iodide), malononitrile and carbon tetrachloride is reported. the cerium(iv) ammonium nitrate (can) was used as a single electron oxidant and ionic liquid (htpb) as a green promoter at ambient temperature. the major advantages of this methodology are experimentally simplicity, environmentally benign, non-toxic and inexpensive catalyst, simple workup procedure, without using column chromatography, all of the compounds were isolated in analytically pure form, excellent yields and short reaction times.

Efficient One-Pot Preparation of 2,4-Dichloro-substituted Pyrano[2,3‑d] pyrimidines and Furo[2,3‑d]pyrimidines Mediated by Ceric Ammonium Nitrate in phosphorus ionic liquid

An efficient, green, and facile four-component reaction for the preparation of 2,4-dichlorosubstituted pyrano [2,3-d]pyrimidines and furo[2,3-d]-pyrimidines through the one-pot condensation of acetophenone derivatives, various aromatic aldehydes (or potassium iodide), malononitrile and carbon tetrachloride is reported. The cerium(IV) ammonium nitrate (CAN) was used as a single electron oxidant and ionic liquid (HTPB) as a green promoter at ambient temperature. The major advantages of this methodology are experimentally simplicity, environmentally benign, non-toxic and inexpensive catalyst, simple workup procedure, without using column chromatography, all of the compounds were isolated in analytically pure form, excellent yields and short reaction times.