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   Mechanistic Investigation of Formation of Some Pharmacological Active Beta-Diketo Compounds and Related Nitrogen Heterocycles  
نویسنده Zargar Noor ,Zaman Khan Khaliq Uz
منبع Advanced Journal Of Chemistry-Section B: Natural Products And Medical Chemistry - 2021 - دوره : 3 - شماره : 2 - صفحه:160 -175
چکیده    Beta-diketo compounds and related n-heterocycles have played a significant role in synthetic organic chemistry. a multistep mechanism for a catalyze base reaction of 1,3-indandione 1 with acetone has been developed to afford a complex molecule, 3-(1,3-dioxo-2- indanylidene)-1,1-dimethyl-1,2,3,4,4d, 9a-hexahydrofluorene 2. pharmacologically active compounds 3, with anticoagulant and antispasmodic properties, have been synthesized through the reaction of 2-substituted 1,3-indandione with β-chloro-vinyl ketones. interaction of phthalimide 4 with benzyl chloride in dmf in presence of k2co3-al2o3 leads to the formation of n-benzyl phthalimide 11.nsubstituted products of type 15 and 16 have been obtained when 6- alkyl or aryl -4(aryl methyl) pyridazine-3(2h)-ones 14 interacted with bromo-ethyl acetate and acetic-anhydride respectively. however, 3- chloro substituted pyridazines 17 afforded 3-mercaptopyridazine derivatives 18 when interacted with thiourea. in this paper, we suggest multistep mechanisms for a series of compounds and all the proposed mechanisms are unknown.
کلیدواژه 3-Indandione ,Benzylation ,Pyridazine ,Acetic-Anhydride ,Bromoethylacetate ,Thiourea ,Mercaptopyridazine
آدرس University Of Kashmir, Department Of Chemistry, India, University Of Kashmir, Department Of Chemistry, India

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