Synthesis, Characterization and Antibacterial Activity of Semicarbazide Based Schiff Bases and Their Pb(Ii), Zr(Iv) and U(Vi) Complexes

Schiff bases are compounds with the general structure r2c=nr’. they can be prepared by the condensation of the primary amines with carbonyl compounds. in this paper, we have synthesized new schiff base ligand (l) by reacting semicarbazide with 2-acetylthiophene in ethanol solvent and its metal complexes have also been synthesized by using zr4+, pb2+ and u6+ ions. schiff bases of semicarbazide are often having promising biological activities like anti-inflammatory, antidepressant, antiglycation, antibacterial, etc. schiff base ligand and metal complexes were characterized and have shown appropriate results when analyzed on uvvis., nmr, ft-ir and antibacterial activities. they were tested against gram- negative [e. coli. (mtcc no: 452)] and gram- positive [bacillus sp (mtcc no: 297)] bacterial strains by using kirby-bauer’s method. schiff base complexes of zirconium [zr(l)4]cl2] and lead [pb(l)2]cl2] were found to be more active against both bacterial strains having a zone of inhibition 11.14 ± 0.2 & 10.23 ± 0.5 mm and 12.02 ± 0.3 & 11.05 ± 0.3 mm on e. coli. and on bacillus species respectively.