Assessment Performance of Immune Systems and Genetics Factors in Patients With Cardiovascular Disease

Background and aim: the cardiovascular diseases are one of the most common causes of the deaths that occurred in developing countries and also they can cause one-third of all deaths in iran and other countries throughout the world. the risk factors for cardiovascular diseases are divided into two categories; the variable risk factors and the non-variable risk factors. the variables are high blood pressure, hyperlipidemia, diabetes mellitus, smoking, sedentary life, obesity, stress, etc. while the non-variables include the males, elders, black races and genetics. recently many have been performed to assess the relationship between the higher eosinophilia and allergy levels with the incidence, progress, and severity of the cardiovascular diseases but the exact correlation between these two still remains to be understood. the current study was designed to measure the levels of allergy and immune system performance amongst patients with cardiovascular diseases in sirjan medicals centers.methods: this case-control study was carried out employing 42 cardiovascular patients randomly selected among those admitted to the medical centers of sirjan university of medical sciences in 2017-2018 as the case and 52 healthy individuals without any history of allergy and parasitic infections as the control group. a questionnaire including some questions such as age, sex, smoking status, familiar inheritance, etc. was completed by each participant after written consent was taken. 7 ml blood was taken from each participant for the cbc measurements and sera were extracted from the rest for ige using elisa.results: there was a significant relationship for the variables such as the family history of cardiovascular disease (p<0.01), diabetes (p<0.02), hyperlipidemia (p<0.001), high blood pressure (p<0.001) and physical activity (p<0.001) between the case and the control groups. the mean ige titer in the case group was 85.3 and 92.44 in the control group. the mean eosinophilia level in peripheral blood was 3.65 in the case and 1.73 in the control group. the differences between the ige and eosinophilia levels in the case and the control groups were statistically significant (p<0.001).conclusion: it can be concluded that the higher amounts of ige antibody and the eosinophilia with genetic factors can be considered in incidence, severity and the progress of different types of cardiovascular diseases so that the cardiologists can rely on the role of these variables in the diagnosis of cardiovascular diseases.